importance of catalase enzyme in virulence of isoniazid resistant st rains of mycobacterium tuberculosis in guineapigs
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abstract
in this study, twenty-five strains of mycobacterium tuberculosis resistant to isoniazid (inh) were isolated from patients with tuberculosis (tb). nine strains (36%) were found to be virulent in guinea-pigs [root index virulence (riv» 1 ]. the remaining sixteen strains (64%) were non-virulent (riv <1). of the nine strains resistant to inh as well as virulent to guinea-pigs, eight of them were found to be catalase positive and only one strain was catalase negative, whereas the remaining sixteen inh resistant strains were catalase negative. a strong association was observed between inh resistance and catalase positivity and virulence (p<0.0001 chi-square test). this study supports the hypothesis that catalase has an important role in the virulence of inh-resistant strains of m tuberculosis.
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Journal title:
medical journal of islamic republic of iranجلد ۱۴، شماره ۳، صفحات ۲۹۳-۲۹۵
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